It depends on the number of other PCI devices that you are exporting to the guest. In the current implementation each virtio-blk disk is a separate PCI device (although Anthony pointed out that you can create multifunction PCI devices which let you break this limit in some narrow circumstances).
How many other PCI devices are you likely to have? Run lspci in a guest to see. Probably you have a host bridge, an ISA bridge for all your legacy devices, a network card, a VGA adapter, a USB controller, an emulated PIIX4 and a memory balloon. That’s 7 devices, and we haven’t even got to disks yet.
PCI is limited to 32 devices in total. So 25 or so virtio block devices is the maximum you would be able to add to a real guest without accepting limitations on things like hotplugging which you would get if you used multifunction devices. (libguestfs is limited to 25 disks but for other reasons to do with limits in febootstrap).
Work is proceeding to remove this limit.
Richard WM Jones 
do these limits still apply. I’ve been told my my linux team that there is still a limit of only 26 SAN disks that I can have per Guest.