In libguestfs 1.11.7 (and some further patches in git) ≥ 1.11.8 you can now use virt-win-reg to list out and update Windows user preferences stored in HKEY_USERS keys.
There are two ways to use this. You can either specify a User SID like:
virt-win-reg Windows 'HKEY_USERS\S-1-5-19\Software\Policies'
or (as a libguestfs extension) you can specify a local user name directly:
virt-win-reg Windows 'HKEY_USERS\rjones\Control Panel'